Molecular biocompatibility of a magnesium-zinc alloy implanted in animals

doi:10.3969/j.issn.2095-4344.2013.16.010

Abstract

Abstract:

BACKGROUND: Previous studies have shown that long-term implantation of magnesium-zinc alloy into animals has a good bio-security.
OBJECTIVE: To observe the molecular biocompatibility of biodegradable magnesium-zinc alloy samples implanted into the rat cecum.
METHODS: Seventy-two Sprague Dawley rats were randomly divided into magnesium-zinc alloy group, medical titanium group and sham-operated group, and there were 24 rats in each group. Then magnesium-zinc alloy samples were embedded in the cecum incision in the magnesium-zinc alloy group. The medical titanium was embedded in the medical titanium group, and just suture was done in the sham-operated group. Prior to and after surgery, alanine transaminase, creatinine, magnesium ion concentrations, serum platelet-derived growth factor concentration and the expression of transforming growth factor-β1 in the cecal tissue were detected by immunohistochemistry.
RESULTS AND CONCLUSION: No significant difference was determined in serum aspartate aminotransferase, creatinine, and magnesium ion concentrations, serum platelet-derived growth factor concentration and the expression of transforming growth factor-β1 among the magnesium-zinc alloy group, medical titanium group and sham-operated group at the same time point following surgery (P > 0.05). However, in the magnesium-zinc alloy group, the level of serum platelet-derived growth factor was significantly increased at different time after surgery (P < 0.05). The magnesium-zinc alloy had no harmful effect on wound healing of the rat cecum, and posed a good biocompatibility with the rat cecum.

Key words: biomaterials, material biocompatibility, magnesium-zinc alloys, pure titanium, wound healing, molecular biocompatibility, cecum, aspartate aminotransferase, creatinine, magnesium ion, platelet-derived growth factor, transforming growth factor-beta 1, National Natural Science Foundation of China

CLC Number:

R318

Yuan Qing-ling, Yan Jun, Zheng Qi, Zhang Shao-xiang, Zhang Xiao-nong. Molecular biocompatibility of a magnesium-zinc alloy implanted in animals[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(16): 2921-2926.

Figures/Tables 4

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